Doctoral Researchers’ Seminar by Konstantin Hein (A07) and Jan Hinrichsen (A01)
On January 23, 2026, EBM doctoral researchers had the opportunity to gain insights into recent advances in neurobiology and biomechanics. Two researchers, Konstantin Hein (A07) and Jan Hinrichsen (A01), shared their current work in an engaging seminar.
Konstantin presented his research on Lamin B1, showing that this protein plays a crucial role in stress-induced mechanical changes and tissue architecture.
Jan discussed progress in in silico modeling of cortical malformations. He highlighted a positive correlation between cell density and shear modulus in HS1 hippocampus samples, mainly driven by glial cells, and a negative correlation in FCD cortex samples, dominated by neurons. His mechanical model captures cell-level changes during development and predicts cortical malformations. Jan also outlined future directions, including studying pathological cells, extending the folding model to FCD II malformations, and moving toward patient-specific predictions.
The seminar provided valuable insights into cutting-edge research and stimulated lively discussion among participants.