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At a joint doctoral seminar in Erlangen, Erica Cecchini presented new insights into the genomic landscape of MOGHE, revealing unexpected Y-chromosomal alterations in epileptic brain lesions, while Soheil Firooz introduced a novel theoretical framework for modeling neural network formation.

How do mechanical cues shape human brain organoids? By growing organoids in hydrogels with defined stiffness and mapping region-specific mechanics using AFM, this collaboration links external forces to internal tissue properties during early neurodevelopment.

On 17 April, the EBM early career researchers Guillaume, Irem, and Lucas attended a Presentation Workshop that challenged them to present without preparation, reflect on their performance through video feedback, and refine their communication skills in a supportive group setting.

In March 2026, Oskar Neumann returned to the University of Cape Town to establish a nanoindentation-based pipeline for mechanotyping brain organoids. The successful setup enables detailed mechanical mapping and strengthens collaboration within EBM.

On Jan 23, 2026, EBM doctoral researchers explored neurobiology & biomechanics. Konstantin Hein presented Lamin B1’s role in tissue mechanics, while Jan Hinrichsen showed in silico models predicting cortical malformations, sparking lively discussion and new insights.

"Niklas Gampl (A05) visited Caren Norden’s lab at the Gulbenkian Institute, Oeiras, Portugal, exploring how mechanosensing and tissue stiffness shape zebrafish retina development. His research bridges zebrafish and Xenopus to uncover forces driving neuroepithelial morphogenesis.

On November 25, EBM Ph.D. students explored magnetic resonance elastography (MRE). Guillaume Flé and Michael Fedders shared insights on MRI sampling techniques and phase unwrapping, giving participants a hands-on look at cutting-edge research and sparking lively discussion.

Majahonkhe Shabangu from the University of Cape Town joined the Institute of Continuum Mechanics and Biomechanics for joint lab shadowing. Together with CRC researchers, they probed the mechanical properties of brain organoids and spheroids, uncovering new insights to guide future testing protocols.

At the Long Night of the Sciences 2025, EBM invited visitors to explore the fascinating world of brain mechanics through interactive exhibits, live demonstrations, and rare insights into real human brain anatomy at the MPZPM Brain Lounge.

From October 9–10, 2025, the EBM community gathered in the picturesque village of Muggendorf for its third annual retreat. Two days of scientific exchange, strategic planning, and team-building—including a lively archery tournament—brought researchers, PIs, and fellows together to connect, reflect, and inspire future progress.